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The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods

Thomsen, Per Hove; Torp, Nor Christian; Dahl, Kitty; Christensen, K; Englyst, Inger; Melin, Karin; Nissen, Judith Becker; Valderhaug, Robert; Weidle, Bernhard; Skarphedinsson, Gudmundur Águst; von bahr, p.l.; Ivarsson, Tord
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URI
http://hdl.handle.net/11250/2385522
Date
2013
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  • Publikasjoner fra Cristin - RBUP [117]
Original version
Child and Adolescent Psychiatry and Mental Health 2013, 7(1)   10.1186/1753-2000-7-41
Abstract
BACKGROUND: This paper describes and discusses the methodology of the Nordic long-term OCD-treatment study (NordLOTS). The purpose of this effectiveness study was to study treatment outcome of CBT, to identify CBT non- or partial responders and to investigate whether an increased number of CBT-sessions or sertraline treatment gives the best outcome; to identify treatment refractory patients and to investigate the outcome of aripiprazole augmentation; to study the outcome over a three year period for each responder including the risk of relapse, and finally to study predictors, moderators and mediators of treatment response.

METHODS: Step 1 was an open and uncontrolled clinical trial with CBT, step 2 was a controlled, randomised non-blinded study of CBT non-responders from step 1. Patients were randomized to receive either sertraline plus CBT-support or continued and modified CBT. In step 3 patients who did not respond to either CBT or sertraline were treated with aripiprazole augmentation to sertraline.

CONCLUSIONS: This multicenter trial covering three Scandinavian countries is going to be the largest CBT-study for paediatric OCD to date. It is not funded by industry and tries in the short and long-term to answer the question whether further CBT or SSRI is better in CBT non-responders.
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